The best biological age test depends on whether you want genetic insights, a current snapshot of health markers, or a repeatable way to track changes. I’d put Hundred Health Comprehensive Lab Test first for its broad biomarker view, while TruAge Complete Collection stands out for people focused on methylation-based age measurement and SelfDecode Healthy Aging and Longevity for genetics-led wellness insights. These tests do not all measure the same thing, so results are not directly interchangeable—and a larger panel does not automatically mean a more useful answer. I compare the six options by what they measure, how the results may guide follow-up, and the practical tradeoffs around testing. Read on for the full breakdown and help choosing the right approach for your goals.
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Key Takeaways
- Hundred Health takes the lead for breadth: its 100-plus biomarkers provide a wider picture of current health than a DNA-only report, though that breadth may be more information than a beginner needs.
- TruAge Complete Collection is the clearest fit for shoppers specifically seeking methylation-focused age estimates; it answers a narrower question than a broad lab panel.
- SelfDecode and PlexusDx put genetic interpretation at the center, so they are better suited to people interested in inherited tendencies than those seeking a direct readout of present-day biomarkers.
- 23andMe Total Health pairs DNA analysis with exome sequencing, giving it a wider genetic scope than a narrowly focused longevity test, but it is not a substitute for a biological-age-specific measurement.
- Aeternum adds another dedicated DNA-based option, making the choice among the genetic kits hinge on the kind of report and follow-up a buyer wants—not the assumption that all DNA tests calculate age the same way.
| SelfDecode Healthy Aging and Longevity At-Home DNA Test |  | Best for Actionable Genetic Guidance | Sample collection: At-home cheek swab | Sample processing: CLIA-certified lab | Analysis: AI analysis across 200 million genetic variants and peer-reviewed research | VIEW LATEST PRICE | See Our Full Breakdown |
| PlexusDx Methylation and Longevity Genetic Test |  | Best for Broad Genetic Aging Reports | Test type: At-home genetic test | Reports: 150+ DNA reports | Genetic variants analyzed: Over 200 million | VIEW LATEST PRICE | See Our Full Breakdown |
| TruAge Complete Collection |  | Best for Multiple Epigenetic Age Metrics | Sample type: Fingertip blood spot | Turnaround time: 2–3 weeks | Core reports: Core Age Tracking, Telomere Length, and Dunedin PACE | VIEW LATEST PRICE | See Our Full Breakdown |
| 23andMe Total Health DNA Test Kit with Exome Sequencing |  | Best for Ongoing Clinician-Supported Health Tracking | DNA analysis: Clinical-grade exome sequencing | Biomarker testing: 55+ cardiometabolic biomarkers, twice yearly | Sample collection: At-home saliva sample and partner-lab blood draws | VIEW LATEST PRICE | See Our Full Breakdown |
| Hundred Health Comprehensive Lab Test with 100+ Biomarkers |  | Best for Broad Lab-Based Health Tracking | Biomarkers: 100+ | Areas covered: Heart and metabolic health, hormones, inflammation, nutrients, stress, and aging | App features: Combines lab results, medical records, wearable data, and recommendations | VIEW LATEST PRICE | See Our Full Breakdown |
| Aeternum DNA Biological Age Test Kit |  | Best for At-Home Saliva Testing | Test type: At-home saliva DNA methylation test | Sample: Saliva | Analysis: DNA methylation markers | VIEW LATEST PRICE | See Our Full Breakdown |
More Details on Our Top Picks
SelfDecode Healthy Aging and Longevity At-Home DNA Test
The SelfDecode Healthy Aging and Longevity At-Home DNA Test is a fit for buyers who want aging-related genetic context paired with practical next steps. Its cheek-swab collection avoids the finger prick required by the TruAge Complete Collection, and the online report offers 50 personalized recommendations based on genetic findings. SelfDecode says its analysis draws on 200 million genetic variants and peer-reviewed research, while sample processing takes place in a CLIA-certified lab. The tradeoff is that this is a genetics-based wellness report, not a direct measurement of current biological age or a medical assessment. Results also depend on mailing the sample and accessing them online. I’d choose it for recommendation-focused genetic insights, but prefer TruAge for multiple epigenetic age metrics.
Pros:- Cheek-swab collection requires no blood draw or needles
- Online report includes 50 personalized recommendations
- Prepaid return mailer is included
- Encrypted data with an option to delete it
Cons:- Genetic findings are for educational and wellness use, not diagnosis or treatment
- Requires mailing the sample and accessing the report online
- Does not describe a direct methylation-based biological age measurement
Best for: People who want at-home, needle-free genetic insights about healthy aging along with a substantial set of personalized wellness recommendations.
Not ideal for: Buyers seeking a direct epigenetic age score, medical diagnosis, or a test that avoids mailing a sample and viewing results online.
- Sample collection:At-home cheek swab
- Sample processing:CLIA-certified lab
- Analysis:AI analysis across 200 million genetic variants and peer-reviewed research
- Report:Online personalized report with 50 recommendations
- Sample return:Prepaid return mailer included
- Privacy:Encrypted; HIPAA/GDPR-aligned; data can be deleted anytime
- Intended use:Educational and wellness purposes only
Our verdict“Choose SelfDecode if you want needle-free, genetics-based aging insights with personalized suggestions, rather than a direct epigenetic age assessment.”
PlexusDx Methylation and Longevity Genetic Test
PlexusDx Methylation and Longevity Genetic Test earns its place for the breadth of topics it covers: more than 150 DNA reports span biological age, telomeres, cognition, muscle loss, and related aging traits. That makes it a broader genetic report bundle than SelfDecode’s 50 recommendations, though SelfDecode gives buyers a clearly stated recommendation count and privacy details that PlexusDx’s supplied product information does not specify. PlexusDx also includes personalized diet, supplement, and lifestyle suggestions, making the volume of reports more useful to someone who wants guidance as well as data. It still relies on an at-home DNA sample that must be mailed back, and the provided details give no result turnaround estimate. This is best for curious report-readers, not for someone prioritizing a defined epigenetic testing method or predictable delivery window.
Pros:- Provides more than 150 reports across aging, longevity, and related traits
- Includes biological age, telomere, cognition, and muscle-loss topics
- Offers personalized diet, supplement, and lifestyle recommendations
- Prepaid mailer is included for sample return
Cons:- Requires collecting and mailing a DNA sample
- Product information does not state how long results take
- The supplied details do not specify privacy protections or the method used to calculate biological age
Best for: People who want a wide-ranging DNA report library covering multiple aging traits and are comfortable collecting and mailing a sample.
Not ideal for: Buyers who need a stated results timeline, detailed privacy terms, or a clearly specified direct epigenetic-age measurement method.
- Test type:At-home genetic test
- Reports:150+ DNA reports
- Genetic variants analyzed:Over 200 million
- Sample return:Prepaid return mailer
- Product dimensions:6.63 x 4.5 x 0.88 inches
- Item weight:2.08 ounces
- Manufacturer:PlexusDX
- Model:Longevity-and-Healthy-Aging-Genetic-Test
Our verdict“Pick PlexusDx if report breadth across genetic aging topics matters more to you than a stated turnaround time or a clearly described age-testing method.”
TruAge Complete Collection
For a roundup centered on biological age, the TruAge Complete Collection stands out because it uses DNA methylation markers to calculate several age-related measures, including epigenetic age and Dunedin PACE. It also reports telomere length, immune cell ratios, and weight-loss response, giving it a more direct biological-age focus than the genetic trait reports from PlexusDx or SelfDecode. The at-home fingertip blood spot is less convenient than their cheek-swab or DNA collection approach, but it supplies the blood sample required for this style of analysis without a clinic visit. Results are listed at 2–3 weeks, so this is not an immediate feedback tool. Choose TruAge for a suite of aging metrics; skip it if a blood spot or several weeks of waiting is a deal-breaker.
Pros:- Uses DNA methylation markers for multiple biological-age metrics
- Includes Dunedin PACE, telomere length, and epigenetic age reports
- Adds immune cell ratio and weight-loss response insights
- Provides a stated 2–3 week turnaround and HIPAA-compliant data handling
Cons:- Requires collecting and mailing a fingertip blood spot
- Results take 2–3 weeks
- The blood collection may be less comfortable than the cheek-swab approach used by SelfDecode
Best for: People who specifically want DNA methylation-based age measures, including Dunedin PACE, from an at-home test.
Not ideal for: People who dislike fingertip blood collection, want results quickly, or prefer a genetics-only cheek-swab test.
- Sample type:Fingertip blood spot
- Turnaround time:2–3 weeks
- Core reports:Core Age Tracking, Telomere Length, and Dunedin PACE
- Epigenetic age reports:Extrinsic and Intrinsic Epigenetic Age
- Additional reports:Immune cell ratios and Weight Loss Response
- Data privacy:HIPAA compliant; no third-party sharing
Our verdict“Choose TruAge if you want multiple methylation-based biological-age measures and can manage a finger-prick sample and multiweek wait.”
23andMe Total Health DNA Test Kit with Exome Sequencing
23andMe Total Health goes beyond a one-time age report by combining clinical-grade exome sequencing with twice-yearly testing of 55+ blood biomarkers. That recurring blood data gives buyers a way to follow health markers over time, while clinician consultations and a preventive care plan add support that the genetic-only SelfDecode and PlexusDx tests do not list. Its biological-age feature is part of a much wider health and ancestry package, rather than the central focus of the product. The tradeoffs are practical: blood testing requires partner-lab visits, eligibility varies by state and region, and registration requires a valid payment method. I’d pick it for people seeking a broader, clinically supported health program, but not for someone who wants a simple at-home biological-age test.
Pros:- Combines exome sequencing with twice-yearly testing of 55+ biomarkers
- Offers virtual consultations with genetics-trained clinicians
- Includes health, pharmacogenetics, wellness, and ancestry features
- Uses CLIA-certified and CAP-accredited labs
Cons:- Blood testing requires partner-lab visits
- Availability is restricted by state and region
- A valid payment method is required at kit registration
Best for: Eligible U.S. adults who want genetic health and ancestry information alongside recurring blood biomarkers and clinician guidance.
Not ideal for: People outside eligible regions, those unwilling to visit partner labs for blood draws, or buyers focused only on a standalone biological-age result.
- DNA analysis:Clinical-grade exome sequencing
- Biomarker testing:55+ cardiometabolic biomarkers, twice yearly
- Sample collection:At-home saliva sample and partner-lab blood draws
- Health features:Genetic health risk, carrier status, pharmacogenetics, wellness, and biological age
- Ancestry features:Historical Matches, Reconstructed Ancestors, and up to 5,000 DNA relatives
- Lab standards:CLIA-certified and CAP-accredited labs
- Eligibility:U.S. residents age 18 or older; state and regional restrictions apply
- Clinical support:Virtual consultations with genetics-trained clinicians
Our verdict“Choose 23andMe Total Health if you want recurring biomarker checks and clinician support as part of a broad health program, not just an age test.”
Hundred Health Comprehensive Lab Test with 100+ Biomarkers
Hundred Health Comprehensive Lab Test is the broad lab-work option in this group, measuring 100+ biomarkers tied to areas such as metabolic and heart health, hormones, inflammation, nutrients, stress, and aging. Unlike TruAge, whose supplied details describe specific methylation-based biological-age metrics, Hundred centers on a wide panel of health markers and does not specify a standalone biological-age score. Licensed physicians review results, and the app can bring lab data together with medical records and wearable information, which may help buyers follow patterns across sources. The tradeoff is that access depends on an in-lab appointment, with several states and territories excluded. I’d choose it for physician-reviewed biomarker tracking, but prefer TruAge when the main goal is a defined epigenetic age assessment.
Pros:- Measures more than 100 biomarkers across multiple health areas
- Licensed physicians review results and provide personalized insights
- App combines lab results, medical records, wearable data, and recommendations
- Supports tracking biomarkers and health data over time
Cons:- The supplied details do not identify a specific biological-age score or testing method
- In-lab appointments are unavailable in several states and territories
- Requires access to an in-lab appointment rather than relying on an entirely at-home sample
Best for: People who want physician-reviewed lab biomarkers across several health areas and a single app for tracking health information over time.
Not ideal for: Buyers seeking a clearly specified methylation-based biological-age score or people in regions without an available lab appointment.
- Biomarkers:100+
- Areas covered:Heart and metabolic health, hormones, inflammation, nutrients, stress, and aging
- App features:Combines lab results, medical records, wearable data, and recommendations
- Progress tracking:Track biomarkers and health data over time
- In-lab availability exclusions:U.S. Virgin Islands, American Samoa, Northern Mariana Islands, Guam, North Dakota, South Dakota, West Virginia, and Hawaii
Our verdict“Choose Hundred Health for physician-reviewed, broad biomarker tracking, but choose TruAge if a specific epigenetic age measure is your priority.”
Aeternum DNA Biological Age Test Kit
Aeternum centers the test on DNA methylation, using a mailed saliva sample to estimate biological age rather than relying on a broad panel of blood biomarkers. That makes it a fit for people who specifically want a methylation-based age estimate and the convenience of collecting a sample at home. Its digital report includes lifestyle recommendations, giving the result a practical next step, and repeat testing may help users follow changes over time. Compared with Hundred Health Comprehensive Lab Test with 100+ Biomarkers, Aeternum focuses more narrowly on methylation and avoids an in-person blood draw; it offers less breadth across other health measures. The tradeoff is the wait: the sample must be mailed to a CLIA-certified lab, and results take a few weeks. I’d choose it for a focused age estimate, not rapid feedback or a wide-ranging biomarker review.
Pros:- At-home saliva collection avoids a doctor visit.
- Uses DNA methylation markers to estimate biological age.
- Digital report includes lifestyle recommendations.
- Prepaid return mailer is included, and repeat testing can support tracking over time.
Cons:- Results take a few weeks rather than arriving quickly.
- The saliva sample must be mailed to a laboratory.
- Its methylation focus provides less breadth than a test covering many blood biomarkers.
Best for: People who want a DNA methylation-based biological-age estimate from a saliva sample at home, plus lifestyle guidance and the option to track results over time.
Not ideal for: People who want quick results, dislike mailing biological samples, or prefer a broad blood-biomarker assessment like Hundred Health’s panel.
- Test type:At-home saliva DNA methylation test
- Sample:Saliva
- Analysis:DNA methylation markers
- Laboratory:CLIA-certified labs
- Results:Digital biological-age report with lifestyle recommendations
- Turnaround:A few weeks
- Included:Saliva collection device, instructions, and prepaid return mailer
Our verdict“Choose Aeternum if you want a mailed-in, saliva-based methylation estimate with digital guidance and can wait a few weeks for results.”
How We Picked
I compared the six options by the question each test can reasonably help answer: whether it estimates age through methylation, describes genetic tendencies, or measures a broader set of current health markers. I also weighed how clearly a buyer can connect the report to a next step, how much testing is involved, and whether the product’s scope fits a focused first purchase or a wider health review. These distinctions matter more than a single headline age number, since different methods can produce different kinds of results.
Hundred Health ranks first for buyers who want a broad biomarker picture, while TruAge ranks highest for methylation-focused age testing. The genetics-oriented kits follow because genetic predispositions are not the same as a direct measure of current biological age; 23andMe’s exome sequencing broadens its genetic scope, but does not by itself make it a dedicated age test. I gave each option a distinct place based on its strongest use case, while factoring in interpretability, scope, and the risk of buying more testing than the buyer can act on.
Factors to Consider When Choosing Best Biological Age Tests
Before choosing a kit, I’d start with the kind of answer you want rather than the product’s use of the phrase “biological age.” A test may estimate age from methylation patterns, interpret genetic variants, or measure health markers that can change over time. Those are related but different jobs, and picking the wrong one can leave you with a report that is interesting but not useful.
Match the test method to your question
If you want an age estimate based on molecular patterns, look for a test that clearly describes its age-measurement method rather than relying on a general longevity label. Genetic tests can highlight inherited tendencies, but they do not necessarily tell you how your body is functioning today. Broad biomarker panels offer current measurements, though a collection of markers is not automatically a single validated age score. A common mistake is comparing numbers from different test types as if they share one scale. Decide whether your priority is an age estimate, genetic context, or a snapshot of present health before comparing kits. The right method is the one that answers that specific question, not the one with the longest feature list.
Check what a result can and cannot change
A test is more useful when its report connects findings to reasonable follow-up, such as discussing an unusual result with a clinician or reviewing a health habit. It cannot diagnose every condition or promise that changing a marker will change your biological age. Genetic findings are often less actionable in the short term than markers that reflect current health, though they may help shape longer-term conversations. Before ordering, check whether the provider explains its limitations and distinguishes risk information from clinical diagnosis. Avoid treating a single score as a verdict on health or lifespan. Ask whether you would know what to do differently after receiving the report.
Think about repeat testing before you buy
Some buyers want a baseline they can revisit, while others only want a one-time overview. If you plan to track change, check whether the same method and sample type can be used again and whether the provider explains how much variation to expect. Changes in sleep, illness, medication, or collection conditions may affect some measurements, so a small difference may not reflect a lasting shift. A repeatable test can be more useful for tracking than a broader one-off panel, but only if the results are interpreted consistently. Decide in advance what interval would make sense and what change would lead you to take action. Without a plan, repeat testing can produce numbers without a clear decision.
Read the privacy and data-use terms
DNA and health biomarker results are sensitive information, so review how the company stores samples and data, how long it retains them, and whether research use is optional. Check whether you can request sample destruction or delete your account data, and whether those choices are explained separately. Genetic tests can reveal information about biological relatives as well as the person tested, which makes privacy preferences especially personal. Do not assume that a home collection kit has the same data practices as a clinical laboratory. A less expansive test may be the better fit if you want to limit the amount of personal information you share. Make this choice before sending a sample, when your options are clearest.
Balance breadth against interpretability
A large panel can reveal more measurements, but it can also create more borderline results and follow-up questions. A focused test may be easier to understand if you have one clear goal, such as exploring methylation-based age estimates. Broad panels make more sense when you want a wider health snapshot and have a plan for discussing findings that need context. Check whether the report explains reference ranges, uncertainty, and the limits of each marker—not just the number of results included. More data is not automatically more precise or more actionable. Choose breadth only when you are prepared to interpret and follow up on it.
Set expectations for clinical follow-up
At-home tests vary in how much clinical support they provide, and a consumer report may not replace care from a qualified clinician. Before ordering, check whether the provider offers professional review, what that service covers, and whether any follow-up requires a separate appointment. If you have symptoms, a known condition, or a result that could affect treatment, use a clinician rather than relying on a wellness report alone. Buyers who simply want educational context may be comfortable with a self-guided report; others may prefer testing arranged through their healthcare team. The test’s value depends partly on whether you can get help interpreting results that fall outside the expected range. Plan that support before testing, especially when a result could prompt medical decisions.
Frequently Asked Questions
Can I compare biological age scores from different test companies?
Usually, not as if they were measurements on one shared scale. Companies may use different sample types, algorithms, markers, and reference groups, so two scores can disagree without either providing a simple apples-to-apples comparison. A methylation estimate also answers a different question from a genetic risk report or a broad biomarker panel. If you want to track change, repeat the same test under similar conditions and focus on the trend within that method. Ask the provider how its score is calculated and what uncertainty applies before treating a number as meaningful.
Should I choose a DNA test or a blood biomarker panel?
Choose based on whether you want inherited context or a view of current health markers. DNA testing can describe genetic tendencies, while a blood panel measures selected markers at the time the sample is collected. Neither type alone gives a complete picture of health or predicts how long you will live. If your main goal is a biological-age estimate, check that the specific test actually reports one and learn how it derives the result. If you want findings that may reflect current habits or health status, a biomarker panel may be a closer fit, with clinical interpretation where needed.
Is a larger biomarker panel automatically a better biological age test?
No. A broad panel can provide useful context, but the number of measurements does not prove that its age estimate is more valid or that every result will be actionable. A focused methylation test may better fit someone who wants a specific age-related measure, while a wider panel may suit someone seeking a general health snapshot. More markers can also mean more results that need explanation or follow-up. Compare the method, report clarity, and intended use—not only the panel size. If the provider does not explain how individual results fit together, breadth may add complexity without answering your main question.
What should I do if an at-home test reports an abnormal result?
Do not treat a consumer report as a diagnosis or make medication changes based on it alone. Check the report’s guidance and contact a qualified healthcare professional, who can decide whether repeat or clinical testing is appropriate. Keep the test name, sample date, and full report available so the result can be interpreted in context. Some markers can vary with collection conditions, recent illness, or other factors, and a clinician can help judge whether that matters. If you have symptoms or an urgent concern, seek medical care rather than waiting for a test company’s interpretation.
How should I choose if I want to track whether my health habits are working?
Look for a test that measures something plausibly responsive to change and can be repeated using the same method. Before the first sample, decide which habits you are changing and when you will retest, so you do not attribute every score shift to one behavior. Keep sample conditions as consistent as the provider recommends, and remember that short-term variation can obscure longer-term patterns. A genetic report may offer useful background but is generally a less direct tool for monitoring a recent habit change than repeatable current-health measurements. Discuss meaningful or unexpected changes with a clinician rather than treating a score as proof of cause and effect.
Conclusion
For the broadest current-health snapshot, I’d choose Hundred Health as the best overall pick, while recognizing that its many markers can call for added interpretation. TruAge Complete Collection is my choice for buyers who specifically want methylation-focused age testing, and SelfDecode is the stronger starting point for a beginner whose interest is genetics-led longevity information. For a wider genetic scope, 23andMe Total Health pairs DNA testing with exome sequencing; PlexusDx and Aeternum are alternatives for shoppers comparing dedicated genetic longevity reports. I would treat best value as the test that answers your question without paying—through added complexity or unused features—for a broader scope you do not need. If you want premium breadth, favor a panel with useful interpretation and follow-up; if you want a specific age estimate, choose the method built for that purpose. The right pick is the one whose result you can understand and use, not simply the one with the most data.
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